InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfsf13b

Summary

InnateDB Protein

IDBP-132001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfsf13b

Protein Name

tumor necrosis factor (ligand) superfamily, member 13b

Synonyms

BAFF; BLyS; D8Ertd387e; TALL-1; TALL1; THANK; TNFSF20; zTNF4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033892

InnateDB Gene

IDBG-131999 (Tnfsf13b)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269PubMed:12867412}.Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000269PubMed:12867412}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269PubMed:12867412}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0001782	B cell homeostasis
GO:0002636	positive regulation of germinal center formation
GO:0006955	immune response
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0031296	B cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0048305	immunoglobulin secretion
GO:0050776	regulation of immune response

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm