InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo16

Summary

InnateDB Protein

IDBP-132022.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo16

Protein Name

myosin XVI

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049345

InnateDB Gene

IDBG-132020 (Myo16)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development (By similarity). Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000250, ECO:0000269PubMed:21946561}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:Q9ERC1}. Note=Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells. {ECO:0000250UniProtKB:Q9ERC1}.

Disease Associations

Tissue Specificity

Expressed predominantly in brain where it is present in the neurons, but not in astrocytes or oligodendrites. {ECO:0000269PubMed:21946561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0051015	actin filament binding

Biological Process

GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0021549	cerebellum development
GO:0048812	neuron projection morphogenesis
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016459	myosin complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2685951

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00193
PR01415

PIRSF

SMART

SM00015
SM00242
SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt