InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnaseh2c

Summary

InnateDB Protein

IDBP-132146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnaseh2c

Protein Name

ribonuclease H2, subunit C

Synonyms

1500026D16Rik; AYP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025864

InnateDB Gene

IDBG-132144 (Rnaseh2c)

Protein Structure

UniProt Annotation

Function

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269PubMed:19923215}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006401

RNA catabolic process

Cellular Component

GO:0005634	nucleus
GO:0032299	ribonuclease H2 complex

Protein Structure and Domains

PDB ID

MGI:1915459

InterPro

IPR013924 Ribonuclease H2, subunit C

PFAM

PF08615

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CQ18

PhosphoSite

PhosphoSite-Q9CQ18

TrEMBL

UniProt Splice Variant

Entrez Gene

68209

UniGene

RefSeq

NP_080892

MGI ID

3P5J

MGI Symbol

Rnaseh2c

OMIM

CCDS

CCDS29471

HPRD

IMGT

EMBL

AF346604 AK011556 AK018776 BC024333

GenPept

AAH24333 AAO49175 BAB27694 BAB31401