Version 5.4
Mus musculus Protein: Iyd
Summary
InnateDB Protein IDBP-132248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Iyd
Protein Name iodotyrosine deiodinase
Synonyms 0610009A07Rik; AI265638; Dehal1;
Species Mus musculus
Ensembl Protein ENSMUSP00000019896
InnateDB Gene IDBG-132246 (Iyd)
Protein Structure
UniProt Annotation
Function Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004447 iodide peroxidase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1917587
InterPro IPR000415 Nitroreductase-like
IPR029479 Nitroreductase
PFAM PF00881
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DCX8
PhosphoSite PhosphoSite-Q9DCX8
TrEMBL
UniProt Splice Variant
Entrez Gene 70337
UniGene Mm.24153
RefSeq NP_081667
MGI ID 3TO0
MGI Symbol Iyd
OMIM
CCDS CCDS56670
HPRD
IMGT
EMBL AK002363 BC023358
GenPept AAH23358 BAB22041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca