Version 5.4
Homo sapiens Protein: UBN1
Summary
InnateDB Protein IDBP-13225.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBN1
Protein Name ubinuclein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262376
InnateDB Gene IDBG-13223 (UBN1)
Protein Structure
UniProt Annotation
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. {ECO:0000269PubMed:14718166, ECO:0000269PubMed:19029251}.
Subcellular Localization Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Note=Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Disease Associations
Tissue Specificity Ubiquitous. Also expressed in numerous tumors and cancer cell lines. {ECO:0000269PubMed:10725330, ECO:0000269PubMed:19029251}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006336 DNA replication-independent nucleosome assembly
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0010923 negative regulation of phosphatase activity
GO:0016032 viral process
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005923 tight junction
GO:0016605 PML body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPG3
PhosphoSite PhosphoSite-Q9NPG3
TrEMBL K7EQR1
UniProt Splice Variant
Entrez Gene 29855
UniGene Hs.440219
RefSeq NP_001072982
HUGO HGNC:12506
OMIM 609771
CCDS CCDS10525
HPRD 11660
IMGT
EMBL AC020663 AC027687 AF108454 AF108455 AF108456 AF108457 AF108458 AF108459 AF108460 AF108461 AK300131 CH471112 U19346
GenPept AAA64188 AAF31755 AAF31756 AAF34869 BAH13219 EAW85249 EAW85250

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca