InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smo

Summary

InnateDB Protein

IDBP-132263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smo

Protein Name

smoothened homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001812

InnateDB Gene

IDBG-132261 (Smo)

Protein Structure

UniProt Annotation

Function

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005113	patched binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001503	ossification
GO:0001570	vasculogenesis
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001755	neural crest cell migration
GO:0001947	heart looping
GO:0002052	positive regulation of neuroblast proliferation
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003007	heart morphogenesis
GO:0003140	determination of left/right asymmetry in lateral mesoderm
GO:0003323	type B pancreatic cell development
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007228	positive regulation of hh target transcription factor activity
GO:0007283	spermatogenesis
GO:0007368	determination of left/right symmetry
GO:0007371	ventral midline determination
GO:0007389	pattern specification process
GO:0007417	central nervous system development
GO:0007494	midgut development
GO:0008284	positive regulation of cell proliferation
GO:0008406	gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010002	cardioblast differentiation
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0021508	floor plate formation
GO:0021561	facial nerve development
GO:0021696	cerebellar cortex morphogenesis
GO:0021794	thalamus development
GO:0021904	dorsal/ventral neural tube patterning
GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953	central nervous system neuron differentiation
GO:0021984	adenohypophysis development
GO:0030857	negative regulation of epithelial cell differentiation
GO:0031017	exocrine pancreas development
GO:0031069	hair follicle morphogenesis
GO:0031076	embryonic camera-type eye development
GO:0031102	neuron projection regeneration
GO:0032474	otolith morphogenesis
GO:0034504	protein localization to nucleus
GO:0035264	multicellular organism growth
GO:0042307	positive regulation of protein import into nucleus
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042693	muscle cell fate commitment
GO:0043066	negative regulation of apoptotic process
GO:0043392	negative regulation of DNA binding
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048565	digestive tract development
GO:0048568	embryonic organ development
GO:0048589	developmental growth
GO:0048663	neuron fate commitment
GO:0048702	embryonic neurocranium morphogenesis
GO:0048703	embryonic viscerocranium morphogenesis
GO:0048741	skeletal muscle fiber development
GO:0048752	semicircular canal morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0048853	forebrain morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050821	protein stabilization
GO:0051451	myoblast migration
GO:0051799	negative regulation of hair follicle development
GO:0060070	canonical Wnt signaling pathway
GO:0060248	detection of cell density by contact stimulus involved in contact inhibition
GO:0060413	atrial septum morphogenesis
GO:0060644	mammary gland epithelial cell differentiation
GO:0060684	epithelial-mesenchymal cell signaling
GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway
GO:0061053	somite development
GO:0061113	pancreas morphogenesis
GO:0071397	cellular response to cholesterol
GO:0072001	renal system development
GO:0072285	mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2000036	regulation of stem cell maintenance
GO:2000826	regulation of heart morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005929	cilium
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0060170	ciliary membrane
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium