InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fezf2

Summary

InnateDB Protein

IDBP-132272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fezf2

Protein Name

Fez family zinc finger 2

Synonyms

AI451466; AI852056; Fez; Fezl; Zfp312;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022262

InnateDB Gene

IDBG-132270 (Fezf2)

Protein Structure

UniProt Annotation

Function

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. {ECO:0000269PubMed:16157277, ECO:0000269PubMed:16314561, ECO:0000269PubMed:16540508, ECO:0000269PubMed:16971467}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16314561}.

Disease Associations

Tissue Specificity

Highly expressed in neocortical layer V, moderately expressed in layer VI. Expressed in subcortically projecting neurons. {ECO:0000269PubMed:16157277, ECO:0000269PubMed:16314561}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007626	locomotory behavior
GO:0008285	negative regulation of cell proliferation
GO:0016358	dendrite development
GO:0021537	telencephalon development
GO:0021542	dentate gyrus development
GO:0021797	forebrain anterior/posterior pattern specification
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021895	cerebral cortex neuron differentiation
GO:0030900	forebrain development
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated