InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r14c

Summary

InnateDB Protein

IDBP-132275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r14c

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 14c

Synonyms

6330514J04Rik; KEPI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045110

InnateDB Gene

IDBG-132273 (Ppp1r14c)

Protein Structure

UniProt Annotation

Function

Inhibitor of the PP1 regulatory subunit PPP1CA. {ECO:0000269PubMed:11812771}.

Subcellular Localization

Endomembrane system {ECO:0000269PubMed:11812771}; Peripheral membrane protein {ECO:0000269PubMed:11812771}.

Disease Associations

Tissue Specificity

Detected in heart, muscle, spinal cord, hippocampus, hypothalamus, thalamus, midbrain, brain stem, cerebellum, brain cortex and olfactory bulb. {ECO:0000269PubMed:11812771}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004865	protein serine/threonine phosphatase inhibitor activity

Biological Process

GO:0007165	signal transduction
GO:0042325	regulation of phosphorylation
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005737	cytoplasm
GO:0012505	endomembrane system
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1923392

InterPro

IPR008025 PKC-activated phosphatase-1 inhibitor

PFAM

PF05361

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4S0

PhosphoSite

PhosphoSite-Q8R4S0

TrEMBL

UniProt Splice Variant

Entrez Gene

76142

UniGene

Mm.308126

RefSeq

NP_597844

MGI ID

MGI Symbol

Ppp1r14c

OMIM

CCDS

CCDS56669

HPRD

IMGT

EMBL

AF407167 AK085997 BC055717

GenPept

AAH55717 AAL83508 BAC39589