InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp13

Summary

InnateDB Protein

IDBP-132355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp13

Protein Name

matrix metallopeptidase 13

Synonyms

Clg; MMP-13; Mmp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015394

InnateDB Gene

IDBG-132353 (Mmp13)

Protein Structure

UniProt Annotation

Function

Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion. {ECO:0000269PubMed:15539485, ECO:0000269PubMed:15563592, ECO:0000269PubMed:17987127, ECO:0000269PubMed:19590036, ECO:0000269PubMed:22880047}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted.

Disease Associations

Tissue Specificity

Detected in epidermal cells and stromal fibroblasts in wounded skin, but not in normal skin (at protein level). Detected in embryonic hypertrophic chondrocytes and newly recruited bone cells at primary ossification centers. After adult bone fracture, detected in periosteum and in chondrocytes in the cartilage. Detected in immature and mature osteoblasts in the fracture callus. Detected in calvaria from neonates. Detected in wounded skin, but not in normal skin. {ECO:0000269PubMed:15563592, ECO:0000269PubMed:17987127, ECO:0000269PubMed:19590036}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	1 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001958	endochondral ossification
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030282	bone mineralization
GO:0030574	collagen catabolic process
GO:0044267	cellular protein metabolic process
GO:0051216	cartilage development
GO:0060349	bone morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1340026

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References