Mus musculus Protein: Mmp12 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-132404.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Mmp12 | ||||||||||||||||||
Protein Name | matrix metallopeptidase 12 | ||||||||||||||||||
Synonyms | AV378681; Mmel; | ||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000005950 | ||||||||||||||||||
InnateDB Gene | IDBG-132400 (Mmp12) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Secreted, extracellular space, extracellular matrix {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:97005 | ||||||||||||||||||
InterPro |
IPR000585
Hemopexin-like domain IPR001818 Peptidase M10, metallopeptidase IPR002477 Peptidoglycan binding-like IPR006026 Peptidase, metallopeptidase IPR016293 Peptidase M10A, stromelysin-type IPR018487 Hemopexin-like repeats IPR021190 Peptidase M10A |
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PFAM |
PF00413
PF01471 PF00045 |
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PRINTS |
PR00138
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PIRSF |
PIRSF001191
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SMART |
SM00235
SM00120 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P34960 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P34960 | ||||||||||||||||||
TrEMBL | Q6GX99 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 17381 | ||||||||||||||||||
UniGene | Mm.488745 | ||||||||||||||||||
RefSeq | NP_032631 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Mmp12 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS22804 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC169512 AK089309 AK089335 AK089452 AK089523 AK090051 AK150596 AK151021 AK151273 AK151933 AK155139 AK155743 AK155747 AK155748 AK155865 AK170360 AK170364 AK170500 AK170798 AK170804 AK170976 AK171006 AK171032 AK171036 AK171176 AK171428 AK171447 AK171448 AK171449 AK171450 AK171466 AK171468 AK171470 AK171472 AK171485 AK171518 AK171542 AK171570 AY622972 BC019135 CT010377 M82831 | ||||||||||||||||||
GenPept | AAA39526 AAH19135 AAT46403 BAC40836 BAC40846 BAC40889 BAC40913 BAC41067 BAE29689 BAE30039 BAE30260 BAE30809 BAE33072 BAE33411 BAE33414 BAE33415 BAE33469 BAE41743 BAE41746 BAE41839 BAE42035 BAE42039 BAE42154 BAE42177 BAE42198 BAE42201 BAE42294 BAE42446 BAE42457 BAE42458 BAE42459 BAE42460 BAE42472 BAE42474 BAE42476 BAE42478 BAE42486 BAE42502 BAE42516 BAE42531 CAJ18584 | ||||||||||||||||||