InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ufl1

Summary

InnateDB Protein

IDBP-132515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ufl1

Protein Name

RIKEN cDNA 1810074P20 gene

Synonyms

1810074P20Rik; AI429228; Kiaa0776; Maxer; mKIAA0776; Rcad;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100059

InnateDB Gene

IDBG-132511 (Ufl1)

Protein Structure

UniProt Annotation

Function

E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1. The function of ufmylation is unknown (By similarity). May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cytoplasm colocalizes with CDK5RAP3. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0071568	UFM1 conjugating enzyme activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0031397	negative regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0071569	protein ufmylation