InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tiam2

Summary

InnateDB Protein

IDBP-132550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tiam2

Protein Name

T-cell lymphoma invasion and metastasis 2

Synonyms

3000002F19Rik; mKIAA2016; STEF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072020

InnateDB Gene

IDBG-132548 (Tiam2)

Protein Structure

UniProt Annotation

Function

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane. {ECO:0000269PubMed:10364228, ECO:0000269PubMed:11707441, ECO:0000269PubMed:12912917, ECO:0000269PubMed:14550769, ECO:0000269PubMed:17320046}.

Subcellular Localization

Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites.

Disease Associations

Tissue Specificity

Expressed in fetal brain (at protein level). Expressed in the olfactory bulb, cortical plate of the cerebral cortex, caudate putamen, hippocampus, ependymal cells of the lateral surface of the lateral ventricles of the brain. Weakly expressed in heart, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:10364228, ECO:0000269PubMed:10512681, ECO:0000269PubMed:11707441, ECO:0000269PubMed:11900975, ECO:0000269PubMed:12912917, ECO:0000269PubMed:14550769}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030426	growth cone

Protein Structure and Domains

PDB ID

MGI:1344338

InterPro

IPR000219 Dbl homology (DH) domain
IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
IPR003116 Raf-like Ras-binding
IPR029071 Ubiquitin-related domain

PFAM

PF00621
PF00595
PF13180
PF00169
PF02196

PRINTS

PIRSF

SMART

SM00325
SM00228
SM00233
SM00455

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6ZPF3