InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dap

Summary

InnateDB Protein

IDBP-132575.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dap

Protein Name

death-associated protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047186

InnateDB Gene

IDBG-132573 (Dap)

Protein Structure

UniProt Annotation

Function

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0070513	death domain binding

Biological Process

GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010507	negative regulation of autophagy
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0034198	cellular response to amino acid starvation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0097190	apoptotic signaling pathway