InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mmp3

Summary

InnateDB Protein

IDBP-132581.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mmp3

Protein Name

matrix metallopeptidase 3

Synonyms

SLN-1; SLN1; Stmy1; STR-1; Str1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034497

InnateDB Gene

IDBG-132579 (Mmp3)

Protein Structure

UniProt Annotation

Function

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0010727	negative regulation of hydrogen peroxide metabolic process
GO:0030334	regulation of cell migration
GO:0030574	collagen catabolic process
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:97010

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References