InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thoc7

Summary

InnateDB Protein

IDBP-132587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thoc7

Protein Name

THO complex 7 homolog (Drosophila)

Synonyms

Nif3l1bp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065819

InnateDB Gene

IDBG-132585 (Thoc7)

Protein Structure

UniProt Annotation

Function

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:12951069}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006397	mRNA processing
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0046784	intronless viral mRNA export from host nucleus

Cellular Component

GO:0000346	transcription export complex
GO:0000347	THO complex
GO:0000445	THO complex part of transcription export complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck