Version 5.4
Mus musculus Protein: Tfb1m
Summary
InnateDB Protein IDBP-132699.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfb1m
Protein Name transcription factor B1, mitochondrial
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035291
InnateDB Gene IDBG-132697 (Tfb1m)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:12532263}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008649 rRNA methyltransferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000154 rRNA modification
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0031167 rRNA methylation
Cellular Component
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID MGI:2146851
InterPro IPR001737 Ribosomal RNA adenine methylase transferase
IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF00398
PRINTS
PIRSF
SMART SM00650
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZM0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 224481
UniGene
RefSeq NP_666186
MGI ID 4GC9
MGI Symbol Tfb1m
OMIM
CCDS CCDS28363
HPRD
IMGT
EMBL AF508971 BC032930
GenPept AAH32930 AAM33651

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca