InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfrp4

Summary

InnateDB Protein

IDBP-132705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfrp4

Protein Name

secreted frizzled-related protein 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002883

InnateDB Gene

IDBG-132703 (Sfrp4)

Protein Structure

UniProt Annotation

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed the ovary. Localized to granulosa cells of periovulatory follicles and corpora lutea. Weakly expressed in adult tissues including kidney, brain and lung. {ECO:0000269PubMed:12960062}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001944	vasculature development
GO:0002092	positive regulation of receptor internalization
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0008285	negative regulation of cell proliferation
GO:0008406	gonad development
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045606	positive regulation of epidermal cell differentiation
GO:0046329	negative regulation of JNK cascade
GO:0046697	decidualization
GO:0055062	phosphate ion homeostasis
GO:0060056	mammary gland involution
GO:0060429	epithelium development
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902174	positive regulation of keratinocyte apoptotic process
GO:2000119	negative regulation of sodium-dependent phosphate transport

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

MGI:892010

InterPro

IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
IPR020067 Frizzled domain

PFAM

PF01759
PF01392

PRINTS

PIRSF

SMART

SM00643
SM00063

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z1N6