Version 5.4
Mus musculus Protein: Sh3yl1
Summary
InnateDB Protein IDBP-132725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3yl1
Protein Name Sh3 domain YSC-like 1
Synonyms AI314953; Ray; YSC84;
Species Mus musculus
Ensembl Protein ENSMUSP00000020997
InnateDB Gene IDBG-132723 (Sh3yl1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle. {ECO:0000269PubMed:10771491}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006661 phosphatidylinositol biosynthetic process
GO:1900027 regulation of ruffle assembly
Cellular Component
GO:0032587 ruffle membrane
Protein Structure and Domains
PDB ID MGI:1346118
InterPro IPR001452 SH3 domain
IPR007461 Ysc84 actin-binding domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF04366
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08641
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 24057
UniGene
RefSeq NP_038737
MGI ID
MGI Symbol Sh3yl1
OMIM
CCDS CCDS25859
HPRD
IMGT
EMBL AK141199 BC010296 BC058557 BC061488 BC110043 D85926
GenPept AAH10296 AAH58557 AAH61488 AAI10044 BAA19679 BAE24582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca