InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nme8

Summary

InnateDB Protein

IDBP-132771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nme8

Protein Name

thioredoxin domain containing 3 (spermatozoa)

Synonyms

1700056P15Rik; Sptrx-2; Txndc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089358

InnateDB Gene

IDBG-132767 (Nme8)

Protein Structure

UniProt Annotation

Function

Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12909633}.

Disease Associations

Tissue Specificity

Testis-specific. Expressed mainly in round spermatids. {ECO:0000269PubMed:12909633}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0045454	cell redox homeostasis