InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDK13

Summary

InnateDB Protein

IDBP-13281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK13

Protein Name

cyclin-dependent kinase 13

Synonyms

CDC2L; CDC2L5; CHED; hCDK13;

Species

Homo sapiens

Ensembl Protein

ENSP00000340557

InnateDB Gene

IDBG-13277 (CDK13)

Protein Structure

UniProt Annotation

Function

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. {ECO:0000269PubMed:16721827, ECO:0000269PubMed:1731328, ECO:0000269PubMed:18480452, ECO:0000269PubMed:20952539}.

Subcellular Localization

Nucleus speckle {ECO:0000269PubMed:16721827}.

Disease Associations

Tissue Specificity

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0006468	protein phosphorylation
GO:0007088	regulation of mitosis
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0016032	viral process
GO:0030097	hemopoiesis
GO:0070816	phosphorylation of RNA polymerase II C-terminal domain

Cellular Component

GO:0002945	cyclin K-CDK13 complex
GO:0005615	extracellular space
GO:0016607	nuclear speck
GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt