Version 5.4
Mus musculus Protein: Il3ra
Summary
InnateDB Protein IDBP-132813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il3ra
Protein Name interleukin 3 receptor, alpha chain
Synonyms CD123; CDw123; SUT-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000088079
InnateDB Gene IDBG-132811 (Il3ra)
Protein Structure
UniProt Annotation
Function In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM- CSF receptors.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed on the cell surface.Isoform 2: Endomembrane system; Single-pass type I membrane protein. Note=Mostly distributed inside the cells, except in the nuclei and is not transported to the cell surface.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0005515 protein binding
Biological Process
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:96553
InterPro IPR003961 Fibronectin, type III
IPR015321 Interleukin-6 receptor alpha, binding
PFAM PF00041
PF01108
PF09240
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P26952
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16188
UniGene Mm.425857
RefSeq NP_032395
MGI ID
MGI Symbol Il3ra
OMIM
CCDS CCDS26827
HPRD
IMGT
EMBL FJ550346 X64534
GenPept ACM24115 CAA45833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca