Version 5.4
Mus musculus Protein: Klhdc10
Summary
InnateDB Protein IDBP-132821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klhdc10
Protein Name kelch domain containing 10
Synonyms 2410127E18Rik; AI593221; mKIAA0265;
Species Mus musculus
Ensembl Protein ENSMUSP00000064594
InnateDB Gene IDBG-132819 (Klhdc10)
Protein Structure
UniProt Annotation
Function Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5. {ECO:0000269PubMed:23102700}.
Subcellular Localization Nucleus. Cytoplasm.Isoform 2: Cytoplasm {ECO:0000269PubMed:23102700}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1924038
InterPro IPR006652 Kelch repeat type 1
IPR011498 Kelch repeat type 2
PFAM PF01344
PF07646
PRINTS
PIRSF
SMART SM00612
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PAR0
PhosphoSite PhosphoSite-Q6PAR0
TrEMBL
UniProt Splice Variant
Entrez Gene 76788
UniGene Mm.475487
RefSeq
MGI ID
MGI Symbol Klhdc10
OMIM
CCDS
HPRD
IMGT
EMBL AK010783 AK039732 AK050289 AK053834 AK085116 AK085130 AK172923 BC060132
GenPept AAH60132 BAB27179 BAC30430 BAC34168 BAC35547 BAC39370 BAC39372 BAD32201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca