Version 5.4
Mus musculus Protein: Polr2d
Summary
InnateDB Protein IDBP-132901.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2d
Protein Name polymerase (RNA) II (DNA directed) polypeptide D
Synonyms 2310002G05Rik; 2610028L19Rik; HSRBP4; RBP4;
Species Mus musculus
Ensembl Protein ENSMUSP00000025106
InnateDB Gene IDBG-132899 (Polr2d)
Protein Structure
UniProt Annotation
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0003824 catalytic activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0031369 translation initiation factor binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0031990 mRNA export from nucleus in response to heat stress
GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0044237 cellular metabolic process
GO:0045948 positive regulation of translational initiation
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
Protein Structure and Domains
PDB ID MGI:1916491
InterPro IPR005574 RNA polymerase II, Rpb4
IPR006590 RNA polymerase II, Rpb4, core
IPR010997 HRDC-like
PFAM PF03874
PRINTS
PIRSF
SMART SM00657
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D7M8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 69241
UniGene
RefSeq NP_081377
MGI ID
MGI Symbol Polr2d
OMIM
CCDS CCDS29111
HPRD
IMGT
EMBL AK011600 BC004810
GenPept AAH04810 BAB27725

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca