InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wdr33

Summary

InnateDB Protein

IDBP-132958.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wdr33

Protein Name

WD repeat domain 33

Synonyms

1110001N06Rik; 2310011G05Rik; 2810021O11Rik; 8430413N20Rik; WDC146;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025264

InnateDB Gene

IDBG-132954 (Wdr33)

Protein Structure

UniProt Annotation

Function

Essential for both cleavage and polyadenylation of pre- mRNA 3' ends. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11162572}.

Disease Associations

Tissue Specificity

Most highly expressed in testis. {ECO:0000269PubMed:11162572}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008150	biological_process

Cellular Component

GO:0005581	collagen trimer
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1921570

InterPro

IPR001680 WD40 repeat
IPR008160 Collagen triple helix repeat
IPR017986 WD40-repeat-containing domain

PFAM

PF00400
PF01391

PRINTS

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K4P0

PhosphoSite

PhosphoSite-Q8K4P0

TrEMBL

Q8VE87

UniProt Splice Variant

Entrez Gene

74320

UniGene

Mm.277705

RefSeq

NP_083142

MGI ID

MGI Symbol

Wdr33

OMIM

CCDS

CCDS29112

HPRD

IMGT

EMBL

AB086191 AC124393 AC131761 AC161511 AK031786 AK050653 BC019526

GenPept

AAH19526 BAC00776 BAC27549 BAC34364