Version 5.4
Mus musculus Protein: Ppp1r42
Summary
InnateDB Protein IDBP-132977.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp1r42
Protein Name leucine rich repeat containing 67
Synonyms 1700011J18Rik; 4930418G15Rik; Lrrc67; TLRR;
Species Mus musculus
Ensembl Protein ENSMUSP00000027049
InnateDB Gene IDBG-132975 (Ppp1r42)
Protein Structure
UniProt Annotation
Function Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis. {ECO:0000269PubMed:21738792}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with alpha tubulin to the manchette of developing spermatids. Detected to nuclear rim in pachytene spermatocytes. Detected at nuclear surface, opposite the acrosome in elongating spermatids. Detected at the microtubule- organizing center (MTOC). Localized to the centrosomal region of late-stage spermatids.
Disease Associations
Tissue Specificity Testis-specific. Expressed in spermatids (at protein level). Testis-specific. {ECO:0000269PubMed:18237440}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0045502 dynein binding
Biological Process
GO:0010921 regulation of phosphatase activity
Cellular Component
GO:0002177 manchette
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID MGI:1921138
InterPro IPR001611 Leucine-rich repeat
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R1Z4
PhosphoSite PhosphoSite-Q8R1Z4
TrEMBL H3BK71
UniProt Splice Variant
Entrez Gene 69312
UniGene Mm.399190
RefSeq NP_663730
MGI ID
MGI Symbol Ppp1r42
OMIM
CCDS CCDS14817
HPRD
IMGT
EMBL AC102570 AK005871 AK015164 AK076637 BC022722
GenPept AAH22722 BAB24290 BAB29732 BAC36427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca