InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Steap1

Summary

InnateDB Protein

IDBP-132985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Steap1

Protein Name

six transmembrane epithelial antigen of the prostate 1

Synonyms

2410007B19Rik; Prss24; Steap;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015796

InnateDB Gene

IDBG-132983 (Steap1)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. {ECO:0000269PubMed:16609065}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:16609065}; Multi-pass membrane protein {ECO:0000269PubMed:16609065}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1917608

InterPro

IPR013130 Ferric reductase transmembrane component-like domain

PFAM

PF01794

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CWR7

PhosphoSite

PhosphoSite-Q9CWR7

TrEMBL

UniProt Splice Variant

Entrez Gene

70358

UniGene

Mm.85429

RefSeq

NP_081675

MGI ID

MGI Symbol

Steap1

OMIM

CCDS

CCDS19077

HPRD

IMGT

EMBL

AK010437 BC061023

GenPept

AAH61023 BAB26938