InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Birc3

Summary

InnateDB Protein

IDBP-133179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc3

Protein Name

baculoviral IAP repeat-containing 3

Synonyms

Api1; Api2; AW107670; Birc2; cIAP-1; cIAP-2; cIAP1; cIAP2; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF49;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013949

InnateDB Gene

IDBG-133177 (Birc3)

Protein Structure

UniProt Annotation

Function

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269PubMed:18621737}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0042326	negative regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051291	protein heterooligomerization
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:2000378	negative regulation of reactive oxygen species metabolic process