InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm1

Summary

InnateDB Protein

IDBP-133365.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm1

Protein Name

glutamate receptor, metabotropic 1

Synonyms

4930455H15Rik; ENSMUSG00000075319; Gm10828; Gprc1a; mGluR1; nmf373; rcw; wobl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037255

InnateDB Gene

IDBG-133363 (Grm1)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity).

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001639	PLC activating G-protein coupled glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008066	glutamate receptor activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007626	locomotory behavior
GO:0019233	sensory perception of pain
GO:0038042	dimeric G-protein coupled receptor signaling pathway
GO:0043408	regulation of MAPK cascade
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051930	regulation of sensory perception of pain
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0005634	nucleus
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0038037	G-protein coupled receptor dimeric complex
GO:0038038	G-protein coupled receptor homodimeric complex
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1351338

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000202 GPCR, family 3, metabotropic glutamate receptor 5
IPR000337 GPCR, family 3
IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR019588 Metabotropic glutamate receptor, Homer-binding domain
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003
PF10606

PRINTS

PR00593
PR01055
PR00248
PR01051

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97772