InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc26a4

Summary

InnateDB Protein

IDBP-133380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc26a4

Protein Name

solute carrier family 26, member 4

Synonyms

Pds; pendrin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001253

InnateDB Gene

IDBG-133378 (Slc26a4)

Protein Structure

UniProt Annotation

Function

Sodium-independent transporter of chloride and iodide.

Subcellular Localization

Membrane {ECO:0000305PubMed:11459928}; Multi-pass membrane protein {ECO:0000305PubMed:11459928}. Cell membrane {ECO:0000269PubMed:11459928}; Multi-pass membrane protein {ECO:0000269PubMed:11459928}. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.

Disease Associations

Tissue Specificity

Throughout the endolymphatic duct and sac, in distinct areas of the utricle and saccule, and in the external sulcus region within the cochlea. {ECO:0000269PubMed:10449762}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0008509	anion transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015111	iodide transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity

Biological Process

GO:0006821	chloride transport
GO:0006885	regulation of pH
GO:0008272	sulfate transport
GO:0009887	organ morphogenesis
GO:0015698	inorganic anion transport
GO:0015705	iodide transport
GO:0032880	regulation of protein localization
GO:0055085	transmembrane transport
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0070062	extracellular vesicular exosome