Version 5.4
Mus musculus Protein: Cpa6
Summary
InnateDB Protein IDBP-133438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpa6
Protein Name carboxypeptidase A6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035435
InnateDB Gene IDBG-133436 (Cpa6)
Protein Structure
UniProt Annotation
Function May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity In brain, highly expressed in the olfactory bulb with lower levels in other regions including cerebral cortex, hippocampus, hypothalamus, striatum and medulla. Within the olfactory bulb, highest levels occur in the mitral and granular layers with lower levels in the internal and external plexiform layers. Moderate levels are found in the epididymis with low levels in colon and spleen. Not detected in adrenal, liver, lung, ovary or testis. At embryonic day 14.5, enriched in eye, ear, osteoblasts, stomach, skin, dorsal root ganglia and throughout the CNS. {ECO:0000269PubMed:15950771}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005575 cellular_component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID MGI:3045348
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
IPR009020 Proteinase inhibitor, propeptide
PFAM PF00246
PF02244
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5U901
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 329093
UniGene Mm.336423
RefSeq NP_808502
MGI ID
MGI Symbol Cpa6
OMIM
CCDS CCDS14819
HPRD
IMGT
EMBL AK078883 AY773477
GenPept AAV40814 BAC37442

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca