InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpc6

Summary

InnateDB Protein

IDBP-133487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpc6

Protein Name

transient receptor potential cation channel, subfamily C, member 6

Synonyms

AV025995; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; TRP-6; Trrp6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057965

InnateDB Gene

IDBG-133485 (Trpc6)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Lung and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007568	aging
GO:0032414	positive regulation of ion transmembrane transporter activity
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070301	cellular response to hydrogen peroxide
GO:0070588	calcium ion transmembrane transport
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0036057	slit diaphragm

Protein Structure and Domains

PDB ID

MGI:109523

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005462 Transient receptor potential channel, canonical 6
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM