InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thrb

Summary

InnateDB Protein

IDBP-133573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thrb

Protein Name

thyroid hormone receptor beta

Synonyms

c-erbAbeta; Nr1a2; T3R[b]; T3Rbeta; Thrb1; Thrb2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022304

InnateDB Gene

IDBG-133569 (Thrb)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0070324	thyroid hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007605	sensory perception of sound
GO:0007621	negative regulation of female receptivity
GO:0008016	regulation of heart contraction
GO:0008050	female courtship behavior
GO:0009887	organ morphogenesis
GO:0030522	intracellular receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060509	Type I pneumocyte differentiation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98743

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR001728 Thyroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR00546

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt