InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ercc4

Summary

InnateDB Protein

IDBP-133612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ercc4

Protein Name

excision repair cross-complementing rodent repair deficiency, complementation group 4

Synonyms

AI606920; Xpf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023206

InnateDB Gene

IDBG-133610 (Ercc4)

Protein Structure

UniProt Annotation

Function

Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001094	TFIID-class transcription factor binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0004520	endodeoxyribonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043566	structure-specific DNA binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411	response to UV
GO:0009650	UV protection
GO:0010834	telomere maintenance via telomere shortening
GO:0032205	negative regulation of telomere maintenance
GO:0033683	nucleotide-excision repair, DNA incision
GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0000110	nucleotide-excision repair factor 1 complex
GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex