InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRA1A

Summary

InnateDB Protein

IDBP-13364.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRA1A

Protein Name

adrenergic, alpha-1A-, receptor

Synonyms

ADRA1C; ADRA1L1; ALPHA1AAR;

Species

Homo sapiens

Ensembl Protein

ENSP00000369960

InnateDB Gene

IDBG-13362 (ADRA1A)

Protein Structure

UniProt Annotation

Function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. {ECO:0000269PubMed:18802028, ECO:0000269PubMed:22120526}.

Subcellular Localization

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Disease Associations

Tissue Specificity

Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. {ECO:0000269PubMed:7737411, ECO:0000269PubMed:8196478, ECO:0000269PubMed:9490024}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004937	alpha1-adrenergic receptor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006915	apoptotic process
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007512	adult heart development
GO:0007568	aging
GO:0008285	negative regulation of cell proliferation
GO:0009725	response to hormone
GO:0010460	positive regulation of heart rate
GO:0016049	cell growth
GO:0032229	negative regulation of synaptic transmission, GABAergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035265	organ growth
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0043410	positive regulation of MAPK cascade
GO:0045760	positive regulation of action potential
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0060073	micturition
GO:0060402	calcium ion transport into cytosol
GO:0060452	positive regulation of cardiac muscle contraction
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071875	adrenergic receptor signaling pathway
GO:0090037	positive regulation of protein kinase C signaling
GO:0097195	pilomotor reflex

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001004 Alpha 1A adrenoceptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00557
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35348