InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgr

Summary

InnateDB Protein

IDBP-133654.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Pgr

Protein Name

progesterone receptor

Synonyms

9930019P03Rik; BB114106; ENSMUSG00000074510; NR3C3; PR; PR-A; PR-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063562

InnateDB Gene

IDBG-133652 (Pgr)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005102	receptor binding
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001542	ovulation from ovarian follicle
GO:0002070	epithelial cell maturation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010629	negative regulation of gene expression
GO:0030879	mammary gland development
GO:0043401	steroid hormone mediated signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050678	regulation of epithelial cell proliferation
GO:0050847	progesterone receptor signaling pathway
GO:0060748	tertiary branching involved in mammary gland duct morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:97567

InterPro

IPR000128 Progesterone receptor
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF02161
PF00104
PF00105

PRINTS

PR00544
PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt