InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2e1

Summary

InnateDB Protein

IDBP-133803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2e1

Protein Name

ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog (yeast)

Synonyms

Ubce5; ubcM2; UbcM3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022296

InnateDB Gene

IDBG-133801 (Ube2e1)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0010390	histone monoubiquitination
GO:0016567	protein ubiquitination
GO:0032020	ISG15-protein conjugation
GO:0033523	histone H2B ubiquitination
GO:0070936	protein K48-linked ubiquitination