InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mkln1

Summary

InnateDB Protein

IDBP-133811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mkln1

Protein Name

muskelin 1, intracellular mediator containing kelch motifs

Synonyms

A130067F06Rik; AU015903; BB154892;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026699

InnateDB Gene

IDBG-133807 (Mkln1)

Protein Structure

UniProt Annotation

Function

Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1351638

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR006594 LisH dimerisation motif
IPR006595 CTLH, C-terminal LisH motif
IPR006652 Kelch repeat type 1
IPR008979 Galactose-binding domain-like
IPR010565 Muskelin, N-terminal

PFAM

PF00754
PF01344
PF06588

PRINTS

PIRSF

SMART

SM00231
SM00667
SM00668
SM00612

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O89050