InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARID3A

Summary

InnateDB Protein

IDBP-13391.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARID3A

Protein Name

AT rich interactive domain 3A (BRIGHT-like)

Synonyms

BRIGHT; DRIL1; DRIL3; E2FBP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263620

InnateDB Gene

IDBG-13387 (ARID3A)

Protein Structure

UniProt Annotation

Function

Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269PubMed:11812999, ECO:0000269PubMed:12692263}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000269PubMed:17400556}. Cytoplasm {ECO:0000269PubMed:17400556}. Note=Shuttles between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter