Version 5.4
Mus musculus Protein: Bfar
Summary
InnateDB Protein IDBP-133944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bfar
Protein Name bifunctional apoptosis regulator
Synonyms 3010001A07Rik; AI666707; AW107665; Bar; Rnf47;
Species Mus musculus
Ensembl Protein ENSMUSP00000063371
InnateDB Gene IDBG-133938 (Bfar)
Protein Structure
UniProt Annotation
Function Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914368
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R079
PhosphoSite PhosphoSite-Q8R079
TrEMBL
UniProt Splice Variant
Entrez Gene 67118
UniGene Mm.223689
RefSeq NP_001171023
MGI ID 1V85
MGI Symbol Bfar
OMIM
CCDS CCDS49769
HPRD
IMGT
EMBL AK013874 AK028592 BC027221
GenPept AAH27221 BAB29029 BAC26022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca