Version 5.4
Mus musculus Protein: Ankrd6
Summary
InnateDB Protein IDBP-133953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ankrd6
Protein Name ankyrin repeat domain 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081800
InnateDB Gene IDBG-133945 (Ankrd6)
Protein Structure
UniProt Annotation
Function Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals. {ECO:0000269PubMed:12183362}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0046330 positive regulation of JNK cascade
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000096 positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2154278
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q69ZU8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 140577
UniGene Mm.451537
RefSeq
MGI ID
MGI Symbol Ankrd6
OMIM
CCDS
HPRD
IMGT
EMBL AK173070 AL831774 AY026320 BC065177 CH466538
GenPept AAH65177 AAK15806 BAD32348 CAM20219 CAM20220 EDL05499

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca