InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prdm14

Summary

InnateDB Protein

IDBP-133956.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdm14

Protein Name

PR domain containing 14

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044245

InnateDB Gene

IDBG-133954 (Prdm14)

Protein Structure

UniProt Annotation

Function

Transcription factor that has both positive and negative roles on transcription. Plays a role in cellular pluripotency (By similarity). Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up- regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. {ECO:0000250, ECO:0000269PubMed:18622394}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Restricted to embryonic stem cells and primordial germ cells. Not detcted in epiblast-derived stem cells. {ECO:0000269PubMed:18622394, ECO:0000269PubMed:20953172}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001708	cell fate specification
GO:0001827	inner cell mass cell fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007281	germ cell development
GO:0009566	fertilization
GO:0010468	regulation of gene expression
GO:0030718	germ-line stem cell maintenance
GO:0034972	histone H3-R26 methylation
GO:0040029	regulation of gene expression, epigenetic
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0044030	regulation of DNA methylation
GO:0048873	homeostasis of number of cells within a tissue