InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncoa2

Summary

InnateDB Protein

IDBP-133999.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ncoa2

Protein Name

nuclear receptor coactivator 2

Synonyms

9530095N19; bHLHe75; D1Ertd433e; GRIP-1; Grip1; KAT13C; SRC-2; TIF-2; TIF2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080413

InnateDB Gene

IDBG-133993 (Ncoa2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0016573	histone acetylation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1276533

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator
IPR017426 Nuclear receptor coactivator

PFAM