Version 5.4
Mus musculus Protein: Tslp
Summary
InnateDB Protein IDBP-134010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tslp
Protein Name thymic stromal lymphopoietin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025237
InnateDB Gene IDBG-134008 (Tslp)
Protein Structure
UniProt Annotation
Function Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:10974033}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1855696
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JIE6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 53603
UniGene
RefSeq NP_067342
MGI ID 4NN7
MGI Symbol Tslp
OMIM
CCDS CCDS29121
HPRD
IMGT
EMBL AF232937 BC130230
GenPept AAF81677 AAI30231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca