InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcb1a

Summary

InnateDB Protein

IDBP-134024.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb1a

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 1A

Synonyms

Abcb4; Evi32; mdr-3; Mdr1a; Mdr3; P-gp; Pgp; Pgy-3; Pgy3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041204

InnateDB Gene

IDBG-134022 (Abcb1a)

Protein Structure

UniProt Annotation

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. {ECO:0000269PubMed:19325113}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042623	ATPase activity, coupled
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0007595	lactation
GO:0007623	circadian rhythm
GO:0009914	hormone transport
GO:0014070	response to organic cyclic compound
GO:0015893	drug transport
GO:0031667	response to nutrient levels
GO:0033280	response to vitamin D
GO:0036146	cellular response to mycotoxin
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0043215	daunorubicin transport
GO:0046618	drug export
GO:0046686	response to cadmium ion
GO:0055085	transmembrane transport
GO:0060548	negative regulation of cell death
GO:0060856	establishment of blood-brain barrier
GO:0071236	cellular response to antibiotic
GO:0071312	cellular response to alkaloid
GO:0071392	cellular response to estradiol stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071475	cellular hyperosmotic salinity response
GO:0071548	response to dexamethasone
GO:0071549	cellular response to dexamethasone stimulus
GO:0097068	response to thyroxine
GO:1902065	response to L-glutamate
GO:2001025	positive regulation of response to drug

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus

Protein Structure and Domains

PDB ID

MGI:97570

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR019195 ABC transporter, ATPase, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005
PF09818

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21447