InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nampt

Summary

InnateDB Protein

IDBP-134051.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nampt

Protein Name

nicotinamide phosphoribosyltransferase

Synonyms

1110035O14Rik; AI314458; AI480535; NAmPRTase; Pbef; Pbef1; Visfatin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020886

InnateDB Gene

IDBG-134049 (Nampt)

Protein Structure

UniProt Annotation

Function

The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. {ECO:0000250, ECO:0000269PubMed:12555668, ECO:0000269PubMed:15381699, ECO:0000269PubMed:19286518}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:12555668}. Secreted {ECO:0000250}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in lymphoid and non- lymphoid tissues. {ECO:0000269PubMed:12555668}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0047280	nicotinamide phosphoribosyltransferase activity

Biological Process

GO:0007565	female pregnancy
GO:0009435	NAD biosynthetic process
GO:0014070	response to organic cyclic compound
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1929865

InterPro

IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR007229 Nicotinate phosphoribosyltransferase family
IPR016471 Nicotinamide phosphoribosyl transferase

PFAM

PF01729
PF04095

PRINTS

PIRSF

PIRSF000484
PIRSF005943

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99KQ4