InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mcm10

Summary

InnateDB Protein

IDBP-134097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcm10

Protein Name

minichromosome maintenance deficient 10 (S. cerevisiae)

Synonyms

2410041F14Rik; AU018508; C330019M07Rik; C79164;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100050

InnateDB Gene

IDBG-134095 (Mcm10)

Protein Structure

UniProt Annotation

Function

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0008283	cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1917274

InterPro

IPR015408 Zinc finger, Mcm10/DnaG-type
IPR015411 Replication factor Mcm10

PFAM

PF09329
PF09332

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VBD2

PhosphoSite

PhosphoSite-Q0VBD2

TrEMBL

UniProt Splice Variant

Entrez Gene

70024

UniGene

Mm.477811

RefSeq

XP_006497596

MGI ID

MGI Symbol

Mcm10

OMIM

CCDS

CCDS15662

HPRD

IMGT

EMBL

AK030780 AK041406 AL928662 BC094576 BC120687 BC120689

GenPept

AAH94576 AAI20688 AAI20690 BAC27135 BAC30933 CAM22575