Version 5.4
Homo sapiens Protein: VASH1
Summary
InnateDB Protein IDBP-13423.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VASH1
Protein Name vasohibin 1
Synonyms KIAA1036;
Species Homo sapiens
Ensembl Protein ENSP00000167106
InnateDB Gene IDBG-13421 (VASH1)
Protein Structure
UniProt Annotation
Function Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16488400, ECO:0000269PubMed:16707096}.
Subcellular Localization Secreted {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16707096}.
Disease Associations
Tissue Specificity Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions. {ECO:0000269PubMed:15467828, ECO:0000269PubMed:16707096}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0007050 cell cycle arrest
GO:0009611 response to wounding
GO:0010596 negative regulation of endothelial cell migration
GO:0016525 negative regulation of angiogenesis
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:1901491 negative regulation of lymphangiogenesis
GO:2000772 regulation of cellular senescence
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7L8A9
PhosphoSite PhosphoSite-Q7L8A9
TrEMBL
UniProt Splice Variant
Entrez Gene 22846
UniGene Hs.603576
RefSeq NP_055724
HUGO HGNC:19964
OMIM 609011
CCDS CCDS9851
HPRD 12353
IMGT
EMBL AB028959 AC007376 AF111169 AL832588 BC009031 BC051896
GenPept AAD44361 AAF02829 AAH09031 AAH51896 BAA82988 CAD89941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca