Version 5.4
Mus musculus Protein: Tm7sf2
Summary
InnateDB Protein IDBP-134293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tm7sf2
Protein Name transmembrane 7 superfamily member 2
Synonyms 3110041O18Rik; ANG1; C14SR; Dhcr14;
Species Mus musculus
Ensembl Protein ENSMUSP00000025713
InnateDB Gene IDBG-134291 (Tm7sf2)
Protein Structure
UniProt Annotation
Function Involved in the conversion of lanosterol to cholesterol. {ECO:0000269Ref.2}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000269Ref.2}; Multi-pass membrane protein {ECO:0000269Ref.2}.
Disease Associations
Tissue Specificity Strongly expressed in liver, weaker in ovary, testis, kidney and brain. {ECO:0000269Ref.2}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0050613 delta14-sterol reductase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID MGI:1920416
InterPro IPR001171 Ergosterol biosynthesis ERG4/ERG24
IPR010721 Protein of unknown function DUF1295
PFAM PF01222
PF06966
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q71KT5
PhosphoSite PhosphoSite-Q71KT5
TrEMBL E0CX92
UniProt Splice Variant
Entrez Gene 73166
UniGene
RefSeq NP_082730
MGI ID
MGI Symbol Tm7sf2
OMIM
CCDS CCDS29490
HPRD
IMGT
EMBL AC131692 AF480070 AK155475 CH466612 EU672836
GenPept AAQ05836 ACF94776 BAE33285 EDL33202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca