InnateDB Protein
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IDBP-134298.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nceh1
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Protein Name
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arylacetamide deacetylase-like 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000045864
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InnateDB Gene
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IDBG-134294 (Nceh1)
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Protein Structure
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Function |
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. {ECO:0000269PubMed:15840715, ECO:0000269PubMed:16978018, ECO:0000269PubMed:18164358, ECO:0000269PubMed:18782767}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Microsome {ECO:0000269PubMed:18782767}.
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Disease Associations |
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Tissue Specificity |
Present in brain, heart, kidney, lung, spinal cord and testis but not liver (at protein level). Expressed in peritoneal macrophages and kidney. {ECO:0000269PubMed:16978018, ECO:0000269PubMed:18782767}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2443191
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InterPro |
IPR013094
Alpha/beta hydrolase fold-3
IPR017157
Arylacetamide deacetylase
IPR029058
Alpha/Beta hydrolase fold
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PFAM |
PF07859
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PRINTS |
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PIRSF |
PIRSF037251
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BLF1
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PhosphoSite |
PhosphoSite-Q8BLF1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
320024
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UniGene |
Mm.481477
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RefSeq |
NP_848887
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MGI ID |
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MGI Symbol |
Nceh1
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OMIM |
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CCDS |
CCDS17271
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HPRD |
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IMGT |
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EMBL |
AK034339
AK045363
AK135837
AK173158
BC082569
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GenPept |
AAH82569
BAC28680
BAC32327
BAD32436
BAE22685
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