InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: D0H4S114

Summary

InnateDB Protein

IDBP-134322.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

D0H4S114

Protein Name

DNA segment, human D4S114

Synonyms

AI325076; D0H4S114; Harp; P311; PTZ17; SEZ17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058132

InnateDB Gene

IDBG-134320 (D0H4S114)

Protein Structure

UniProt Annotation

Function

May have roles in cellular differentiation. Ectopic expression induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. May also have neural functions. Promotes axonal regeneration and augments motility of gliomas. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation. {ECO:0000269PubMed:12417574, ECO:0000269PubMed:14985127, ECO:0000269PubMed:16934802, ECO:0000269PubMed:18664493}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain and fetal lung. {ECO:0000269PubMed:16484684, ECO:0000269PubMed:8261136}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0031103	axon regeneration
GO:0045664	regulation of neuron differentiation